Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide

نویسندگان

  • Alexia Arpel
  • Coralie Gamper
  • Caroline Spenlé
  • Aurore Fernandez
  • Laurent Jacob
  • Nadège Baumlin
  • Patrice Laquerriere
  • Gertraud Orend
  • Gérard Crémel
  • Dominique Bagnard
چکیده

The transmembrane domains (TMD) in membrane receptors play a key role in cell signaling. As previously shown by us a peptide targeting the TMD of neuropilin-1 (MTP-NRP1), blocks cell proliferation, cell migration and angiogenesis in vitro, and decreases glioblastoma growth in vivo. We now explored the clinical potential of MTP-NRP1 on breast cancer models and demonstrate that MTP-NRP1 blocks proliferation of several breast cancer lines including the MDA-MB-231, a triple negative human breast cancer cell line. In models with long term in vivo administration of the peptide, MTP-NRP1 not only reduced tumor volume but also decreased number and size of breast cancer metastases. Strikingly, treating mice before tumors developed protected from metastasis establishment/formation. Overall, our results report that targeting the TMD of NRP1 in breast cancer is a potent new strategy to fight against breast cancer and related metastasis.

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عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2016